Laksh Finechem Private Limited

Nimodipine:

Chemical Names: Nimodipine; Nimotop; Periplum; Nimodipino; Nimodipinum

Molecular Formula: C₂₁H₂₆N₂O₇

Molecular Weight: 418.44034 g/mol

CAS No: 66085-59-4

USE : Nimodipine is a calcium channel blockader with preferential cerebrovascular activity. It has marked cerebrovascular dilating effects and lowers blood pressure.

Chemical Name : 1,4-Dihydro-2,6-dimethyl-4-(3-nitrophenyl)-3,5-pyridinedicarboxylic acid 2-methoxyethyl (2E)-3-phenyl-2-propenyl ester;
Molecular Formula : C₂₇H₂₈N₂O₇
Molecular Weight : 492.54
C.A.S No. : 132203-70-4
USE : Cilnidipine (INN) is a calcium channel blocker. Cilnidipine is the novel calcium antagonist accompanied with L-type and N-type calcium channel blocking function. It was jointly developed by Fuji Viscera Pharmaceutical Company, Japan and Ajinomoto, Japan and approved to come into market for the first time and used for high blood pressure treatment in 1995. Compared with other calcium antagonists. cilnidipine can act on the N-type calcium channel that existing sympathetic nerve end besides acting on L-type calcium channel that similar to most of the calcium antagonists. Cilnidipine is approved for use in Japan, China,India, Korea and some European countries.

1.0. Appearance : Light yellow crystalline powder.

2.0. Solubility : Practically insoluble in water, Sparingly soluble in ethanol

3.0. Identification :
a) By IR : The transmission minima (absorption maxima) in the spectrum obtained with the substance to be examined correspond in position and relative size to those in the spectrum obtained with the Cilnidipine working standard.
b) By HPLC : The retention time of the major peak in the chromatogram of the sample preparation corresponds in that of the peak due to Cilnidipine in the chromatogram of the standard preparation, as obtained in Assay.

4.0. Melting Point : 105⁰C to 110⁰C

5.0. Related Substances (by HPLC) : a) Any Single Impurity : Not more than 0.5%
b) Total Of Impurities : Not more than 1.0%

6.0. Heavy Metals : Not more than 10 ppm

7.0. Loss on drying : Not more than 0.5 %

8.0. Ignited residue (Sulphated Ash): Not more than 0.1 % w/w

9.0. Assay ( On Dried Basis) : Not less than 99.0% and not more than 102.0%.

10.0. Residual solvent :
a) Methanol : Not more than 3000 ppm
b) Isopropyl Alcohol : Not more than 5000 ppm
c) Toluene(NMT 890 ppm)

11.0. Particle Size :
a) 90% Particles are less than 30 micrones
b) 50% Particles are less than 20 micrones
c) 10% Particles are less than 10 micrones.

We are currently developing Benidipine Powder, a potential active pharmaceutical ingredient (API) belonging to the class of calcium channel blockers (dihydropyridine type). Known for its vasodilatory effects, Benidipine may be used in the management of hypertension and other cardiovascular conditions.

• Appearance: White to off-white crystalline powder

• Molecular Formula: C₂₅H₂₈N₂O₃

• Molecular Weight: 396.5 g/mol

• Solubility: Sparingly soluble in water; soluble in ethanol and acetone

• Melting Point: Approx. 172°C to 174°C

• Density: ~1.1 g/cm³

• Odor: Odorless or faint neutral odor

• Structure: Contains a dihydropyridine ring, phenyl groups, and hydrophilic ester group

• Form: Base or hydrochloride salt (as per formulation requirements)

• Therapeutic Class: Calcium channel blocker / Antihypertensive

This product is currently under development at our facility. Samples, documentation, and commercial availability will be provided upon successful validation and scale-up.

For collaboration, inquiries, or future requirement planning, please feel free to contact us.

Gadoteric acid is a diagnostic contrast agent used with magnetic resonance imaging (MRI) to provide contrast enhancement for intracranial and spinal lesions with abnormal blood brain barrier or abnormal vascularity.

• A sudden drop in your blood pressure may occur, especially when you first start taking Azelnidipine. To lower the chance of feeling dizzy or passing out, rise slowly if you have been sitting or lying down.
• It can cause ankle or foot swelling. To reduce the swelling, raise your legs while you are sitting down. Talk to your doctor if it does not go away.
• It may cause dizziness. Do not drive or perform any activity that requires mental focus until you know how Azelnidipine affects you. 
• Inform your doctor if you are pregnant, planning a pregnancy or breastfeeding.

We introduce ourselves as a GMP, FDA, GLP, HALAL and ISO certified company, specializing in the production of several Pharmaceutical Active Ingredients and it's intermediates.

Our core products are as under:

1. CHIRAL RESOLVING AGENTS (DI-ETHYL-D-TARTRATE, DI-ETHYL-L-TARTRATE, etc.)

2. IODINE DERIVATIVES

3. IODOPHOR / SANITIZER

4. ETHYL GLYOXYLATE 

5. API & API INTERMEDIATES

A comprehensive list of products offering is enclosed for your reference and record Laksh_Product_List_Click

We have state of the art manufacturing and testing infrastructure viz Glass Lined Reactors, SS316L Reactors, Filtration and Drying Equipment, HPLC, GC, etc. 

We cater to the requirements of leading pharmaceutical companies worldwide, meeting there stringent requirements based on USFDA guidelines. 

Please find the company profile for insight into our range of products and our manufacturing capabilities Company_Profile_Click.

We will be glad to receive your inquiries about our range of products. 

Looking forward to developing a sound and long-term business relationship with you! 

Have a great day!