Laksh Fine Chem Pvt. Ltd. is GMP certified Active Pharmaceutical Ingredients (APIs) and Pharmaceutical Intermediates Manufacturing and Exporting Unit, established in 2009, Located at GIDC of Vitthal Udyognagar, Anand, Gujarat. INDIA.
Laksh Fine Chem continuously engaged in the developing Advanced APIs through R&D using innovative technologies, taking full advantage of our core competencies, equipment and facilities. Our innovative team of experts has a proven track record in: process development, process optimization and scale-up in a timely manner by knowledge of their superior chemistry and problem-solving skills coupled with our many years of experience, which help us in rendering value in terms of cost, speed and quality and we do so adhering to the highest standards of ethics and integrity.
We also work with an efficient and professional team, which is market savvy and capable of adapting to the demands of the business. We concentrate on your requirements and entrust all your outsourcing hassles to our experienced hands for supplying High Quality APIs at Competitive Prices Complying with Stringent Regulatory Requirements.
Our List Of Products in APIs are as below:
Chemical Name : 1,4-Dihydro-2,6-dimethyl-4-(3-nitrophenyl)-3,5-pyridinedicarboxylic acid 2-methoxyethyl (2E)-3-phenyl-2-propenyl ester;
Molecular Formula : C27H28N2O7
Molecular Weight : 492.54
C.A.S No. : 132203-70-4
Physical & Chemical Properties: Light Yellow crystalline powder, Practically insoluble in water, Sparingly soluble in ethanol
USE : Cilnidipine (INN) is a calcium channel blocker. Cilnidipine is the novel calcium antagonist accompanied with L-type and N-type calcium channel blocking function. It was jointly developed by Fuji Viscera Pharmaceutical Company, Japan and Ajinomoto, Japan and approved to come into market for the first time and used for high blood pressure treatment in 1995. Compared with other calcium antagonists. cilnidipine can act on the N-type calcium channel that existing sympathetic nerve end besides acting on L-type calcium channel that similar to most of the calcium antagonists. Cilnidipine is approved for use in Japan, China,India, Korea and some European countries.
1.0. Appearance : Light yellow crystalline powder.
2.0. Solubility : Practically insoluble in water, Sparingly soluble in ethanol
3.0. Identification :
a) By IR : The transmission minima (absorption maxima) in the spectrum obtained with the substance to be examined correspond in position and relative size to those in the spectrum obtained with the Cilnidipine working standard.
b) By HPLC : The retention time of the major peak in the chromatogram of the sample preparation corresponds in that of the peak due to Cilnidipine in the chromatogram of the standard preparation, as obtained in Assay.
4.0. Melting Point : 1050C to 1100C
5.0. Related Substances (by HPLC) : a) Any Single Impurity : Not more than 0.5%
b) Total Of Impurities : Not more than 1.0%
6.0. Heavy Metals : Not more than 10 ppm
7.0. Loss on drying : Not more than 0.5 %
8.0. Ignited residue (Sulphated Ash): Not more than 0.1 % w/w
9.0. Assay ( On Dried Basis) : Not less than 99.0% and not more than 102.0%.
10.0. Residual solvent :
a) Methanol : Not more than 3000 ppm
b) Isopropyl Alcohol : Not more than 5000 ppm
c) Toluene(NMT 890 ppm)
11.0. Particle Size :
a) 90% Particles are less than 30 micrones
b) 50% Particles are less than 20 micrones
c) 10% Particles are less than 10 micrones.
|Minimum Order Quantity||50 Kilogram|
Chemical Names: Nimodipine; 66085-59-4; Nimotop; Periplum; Nimodipino; Nimodipinum
Molecular Formula: C21H26N2O7
Molecular Weight: 418.44034 g/mol
CAS No: 66085-59-4
USE : Nimodipine is a calcium channel blockader with preferential cerebrovascular activity. It has marked cerebrovascular dilating effects and lowers blood pressure.
01. Appearance : Light yellow or yellow, crystalline powder.
02. Solubility : Practically insoluble in water, freely soluble in ethyl acetate, sparingly soluble in anhydrous ethanol.
03. Identification :
a) Optical rotation : -0.10° to + 0.10°
b) By Infrared Absorption Spectrophotometry : The IR spectrum of the sample should be concordant with the spectrum of Nimodipine reference standard.
04. Appearance of solution : Solution S is clear.
05. Optical Rotation : -0.10° to + 0.10°
06. Related Substance by HPLC :
a) Impurity-C : NMT 0.2 %
b) Unspecified Impurity (Each impurity) : NMT 0.1 %
c) Total Impurities : NMT 0.5 %.
07. Loss on drying (at 1050 c) : Not More Than 0.5 %.
08. Residue On Ignition : Not more than 0.1 % W/W
09. Sulfated ash : Not more than 0.1 %.
10. Assay By Titrimetry (on dried basis) : 98.5 % to 101.5 %
11. Additional Test : Melting Point : 1200 C to 1250 C
12. Assay By HPLC (on dried basis) : 98.5 % to 101.5 %.
|Grade Standard||Medicine Grade|
Chemical Names: Magnevist; Gadopentetate Dimeglumine; Gd-DTPA; Gadolinium dtpa; Meglumine gadopentetate; Gadopentetic acid dimeglumine salt;
Molecular Formula: C28H54GdN5O20
Molecular Weight: 937.99986 g/mol
CAS NO : 86050-77-3
USE : Magnevist is a complex of gadolinium with a chelating agent, diethylenetriamine penta-acetic acid (DTPA see Pentetic Acid), that is given to enhance the image in cranial and spinal MRIs.
1.0. Appearance: White or off-white crystalline powder, odorless, hydroscopic.
2.0. Solubility: Freely soluble in water, practically insoluble in alcohol and acetone.
3.0. Clarity and colour solution: Clarity and colourless, if colored, compare with no.1 yellow standard colorimetric solution, no deeper. If turbid compare with no.1 turbidity standard solution, not deeper.
4.0. Loss of drying : Not more than 10.0%.
5.0 Free DPTA and GADOLINIUM:
1) The solution should be: orange red if both DTPA and GD are ok;-if solution is orange -yellow, the DTPA excess,-if orange –violate the Gd is excess.
2) The pentetic acid:-Not more than 0.1%
3)Gd:-Not more than 0.1%
6.0. Meglumine : Not more than 0.1 %.
7.0. Assay: 98.0-102.0 %.
Chemical Names: Levosulpiride; (-)-Sulpiride; (S)-(-)-sulpiride; 23672-07-3; S-(-)-Sulpiride; Levopraid
USE : Levosulpiride is used in the treatment of psychoses, particularly negative symptoms of schizophrenia, anxiety disorders, dysthymia, vertigo, dyspepsia, irritable bowel syndrome . Chemically, it is the (S)-(−)-ofsulpiride
Molecular Formula : C15H23N3O4S
Molecular Weight : 341.42 g/mol
CAS NO : 23672-07-3
01. Description : A white to cream colour powder
02. Solubility : Practically insoluble in water Sparingly soluble in methanol., Slightly soluble in alcohol and in methylene chloride.
a) Melting Point : 182-188°C
b) BY IR : The absorption spectrum obtained with the test to be concordant with the spectrum of levosulpiride RS/WS.
c) By TLC : To Comply
d) By Fluorescence test : The Solution shows blue fluorescence.
04. Specific Optical Rotation : Between- 60º and -69º
05. Related Substances by HPLC :
a) Any Single impurity: Not more than 0.5 %
b).Total Of Impurities : Not more than 1.0 %
06. Chlorides : Not more than 100 ppm
07. Heavy Metals : Not more than 10 ppm
08. Loss on Drying: Not more than 0.5 % w/w
09. Sulphated Ash : Not more than 0.10 % w/w
10. Assay ( On Dried Basis): Between 98.5 % to 101.0 % w/w
11. Residual Solvent: Ethylene Glycol (620 ppm)
12. Particle Size:
a) 90% Particles are less than 50 micrones
b) 50% Particles are less than 20 micrones
c) 10% Particles are less than10 micrones
13. Untapped Density: 0.45 to 0.55 gm/ml
14. Tapped Density : 0.65 to 0.75 gm/ml